Pre-PROTO-PRIME: stereotactic body proton therapy to the prostate and pelvic nodes for high-risk and node-positive prostate cancer — feasibility, acute toxicity and dosimetric insights
SBPT to the prostate and pelvic lymph nodes is clinically feasible, with low acute toxicity and superior OAR sparing compared to photon-based SBRT. The dosimetric data from this study were used to propose volumetric dose constraints for SBPT planning of the prostate and pelvis. These preliminary results substantiate the rationale for the prospective PROTO-PRIME trial, which will investigate the clinical benefits of SBPT relative to SBRT in this patient population.
Authors
- Lilawati Meena
- Mahima Tiwari
- Srinivas Chilukuri (ORCID: https://orcid.org/0000-0003-0491-7935)
- Manikandan Arjunan
- Priyamvada Maitre (ORCID: https://orcid.org/0000-0002-8878-7914)
- Vedang Murthy (ORCID: https://orcid.org/0000-0001-6011-9319)
- Neha Jain (ORCID: https://orcid.org/0000-0003-3827-5598)
- Vysakh Raveendran (ORCID: https://orcid.org/0000-0001-9549-4231)
- Dayananda Sharma (ORCID: https://orcid.org/0000-0002-4249-3574)
- Reena Phurailatpam (ORCID: https://orcid.org/0000-0001-9719-4777)
- Rajesh Selvaraj
- Ramakrishna Kamath
- Sham Sundar
- V. Subramani (ORCID: https://orcid.org/0000-0001-6612-9008)
- L.N. Chaudhari (ORCID: https://orcid.org/0000-0001-8321-9507)
- Priyanka Halsana (ORCID: https://orcid.org/0009-0006-7919-1963)
- Aishwarya Guruvaiah
- Vineeth Kumaar
Institutions
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
- Apollo Proton Cancer Centre (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.ctro.2025.101084
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00