Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry
T cells can express TCRs that recognize multiple AQPs. Autoimmunity can be initiated through molecular mimicry between distinct self-antigens such as AQP4 and AQP5 that are expressed in separate organs. These findings suggest that T-cell self-antigen mimicry may contribute to coexistence of NMO with other autoimmune conditions, such as Sjögren syndrome.
Authors
- Juliano André Boquett (ORCID: https://orcid.org/0000-0002-6437-789X)
- Jill A. Hollenbach (ORCID: https://orcid.org/0000-0001-6572-7962)
- Collin M. Spencer (ORCID: https://orcid.org/0000-0002-3999-7499)
- Sharon A. Sagan (ORCID: https://orcid.org/0009-0008-2212-5783)
- Scott S. Zamvil (ORCID: https://orcid.org/0000-0003-2720-9915)
- Joseph J. Sabatino (ORCID: https://orcid.org/0000-0002-6804-7441)
- Carson E. Moseley (ORCID: https://orcid.org/0000-0001-8859-3792)
- Lawrence Steinman (ORCID: https://orcid.org/0000-0002-2437-2250)
- Raymond A. Sobel (ORCID: https://orcid.org/0000-0002-0477-9002)
- Jonathan B. Rothbard
Institutions
- University of California, San Francisco (US)
- VA Palo Alto Health Care System (US)
- Neurological Surgery (US)
- University of San Francisco (US)
- Stanford University (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1212/nxi.0000000000200517
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00