Meta-Analysis of Bias in Non–Small Cell Lung Cancer External Control Arms That Use Real-World Progression-Free Survival as the End Point
The close alignment of results between RCT and RWD increases confidence that RWD ECs using the rwPFS end point in this disease setting can provide context for future single-arm clinical trials despite potential differences in end point assessment.
Authors
- Devin Incerti (ORCID: https://orcid.org/0000-0002-4479-8750)
- Chris Harbron (ORCID: https://orcid.org/0000-0002-4353-5780)
- Thanh G.N. Ton (ORCID: https://orcid.org/0000-0002-5182-3600)
- Michael T. Bretscher (ORCID: https://orcid.org/0009-0003-1839-8264)
- Sanaa Bahmane (ORCID: https://orcid.org/0009-0005-4264-8782)
Institutions
- Roche (Switzerland) (CH)
- Princeton University (US)
- University Hospital of Basel (CH)
- Roche (United Kingdom) (GB)
Publication Details
- Journal
- JCO Clinical Cancer Informatics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1200/cci-25-00198
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00