BMAL1 insufficiency increases the risk of thoracic aortic aneurysm and dissection
BMAL1 insufficiency increases the risk of TAAD by inducing VSMC apoptosis via down-regulation of REV-ERBα. BMAL1 and REV-ERBα may serve as pharmacological targets for TAAD prevention and therapy.
Authors
- Chunxiu Huo
- Wenyu Song (ORCID: https://orcid.org/0000-0002-1109-3148)
- Jinmiao Chen (ORCID: https://orcid.org/0000-0003-4326-0665)
- Peiyi Zhou
- Hao Lai (ORCID: https://orcid.org/0000-0003-0277-9364)
- Guangguo Fu (ORCID: https://orcid.org/0000-0001-6937-181X)
- Kangjie Shen
- Lieyang Qin (ORCID: https://orcid.org/0000-0002-7412-1687)
- Lijie Shi (ORCID: https://orcid.org/0000-0003-2290-3983)
- Qing Li (ORCID: https://orcid.org/0000-0002-6898-5219)
- Yun‐Chi Tang (ORCID: https://orcid.org/0000-0001-9385-2787)
- Le Xiao (ORCID: https://orcid.org/0000-0001-9703-1265)
- Lingyan Ni
- Chunsheng Wang (ORCID: https://orcid.org/0000-0001-7501-2282)
- Lai Wei (ORCID: https://orcid.org/0000-0001-6008-8567)
- Xueting Zhang (ORCID: https://orcid.org/0000-0002-0003-0475)
- Huanhuan Sun (ORCID: https://orcid.org/0000-0003-1847-9753)
- Liqi Huang
- Hung-Chun Chang
- Meiqi Liu (ORCID: https://orcid.org/0000-0003-0056-7296)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Shanghai Medical Information Center (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Shanghai Institutes for Biological Sciences (CN)
- Hegang People's Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/cvr/cvaf259
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00