Integrative analysis of RNA expression signatures and recurrent genomic alterations before treatment: link to menopausal status, short-term endocrine therapy response and disease-free survival in luminal breast cancer
Endocrine resistance in luminal breast cancer is characterized by elevated immune signatures, increased proliferation, and specific genomic alterations. The integration of clinical information, gene expression patterns, and genetic data enhances patient stratification and potentially informs treatment decisions. These findings support the use of integrative analyses to guide personalized endocrine therapy and improve outcomes.
Authors
- Clarissa Gerhäuser (ORCID: https://orcid.org/0000-0002-5792-3901)
- Oleg Gluz (ORCID: https://orcid.org/0000-0001-6019-7544)
- Stephan Bartels (ORCID: https://orcid.org/0000-0002-8903-2345)
- Matthias Christgen (ORCID: https://orcid.org/0000-0002-0891-7839)
- Christoph Plass (ORCID: https://orcid.org/0000-0003-2554-3952)
- HH Kreipe
- Ronald Kates (ORCID: https://orcid.org/0000-0003-3550-1051)
- Mieke Raap (ORCID: https://orcid.org/0000-0001-8338-6209)
- Nadia Harbeck (ORCID: https://orcid.org/0000-0002-9744-7372)
- Christine zu Eulenburg (ORCID: https://orcid.org/0000-0001-9365-5548)
- Henriette Christgen
- Ulrich Mansmann (ORCID: https://orcid.org/0000-0002-9955-8906)
- U. Nitz
- Sherko Kuemmel (ORCID: https://orcid.org/0000-0001-9355-494X)
- Leonie Donata Kandt
- Guoying Zhang (ORCID: https://orcid.org/0000-0002-3291-630X)
- Hong Ni
- Monika Graeser
- Lidiya Mishieva
Institutions
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- University of Bremen (DE)
- Heidelberg University (DE)
- Bethesda Hospital (IN)
- Medizinische Hochschule Hannover (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Zimmer Biomet (Germany) (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Breast Center (CH)
- German Breast group (DE)
- Evangelisches Krankenhaus Bethesda Mönchengladbach (DE)
- Women‘s Healthcare Group (DE)
- Ludwig-Maximilians-Universität München (DE)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105913
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- National Cancer Institute