Effects of Different Treatment Sequences on the Efficacy of Combined Periodontal-Endodontic Lesions: A Systematic Review and Meta-Analysis
The endodontic-first approach significantly improved the clinical outcomes of combined PELs compared with periodontal-first or periodontal-only treatment. However, significant heterogeneity across lesion categories and interventions, together with evidence of publication bias, highlights the need for cautious interpretation and underscores the importance of future well-designed, standardised RCTs.
Authors
- Jiaqi Wang (ORCID: https://orcid.org/0009-0000-4708-7412)
- Min Hu (ORCID: https://orcid.org/0000-0002-0788-8765)
- Peng Wang (ORCID: https://orcid.org/0000-0003-2359-908X)
- Fei Sun (ORCID: https://orcid.org/0000-0001-8189-5122)
- Qiuyan Zhu (ORCID: https://orcid.org/0009-0006-6707-1710)
- Yue Gao
- Zhou Yin (ORCID: https://orcid.org/0009-0001-2906-5866)
- Min Feng (ORCID: https://orcid.org/0000-0001-5376-4408)
- Chen Meng-hua (ORCID: https://orcid.org/0000-0002-0950-2440)
- Yihong Fan
- Shan Qian
- A. Cai
- Yingying Shou
Institutions
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.identj.2025.104021
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00