Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal Stromal Tumors through PGK1-Mediated Metabolic Reprogramming
Cross-talk between cancer-associated fibroblasts and cancer cells promotes metabolic and tumor microenvironmental reprogramming that drives imatinib resistance in gastrointestinal stromal tumors, providing potential targets to overcome resistance and improve therapeutic outcomes.
Authors
- Chao Li (ORCID: https://orcid.org/0000-0001-9768-4004)
- Tuo Yi (ORCID: https://orcid.org/0000-0002-1267-2141)
- Kuntang Shen (ORCID: https://orcid.org/0000-0002-9600-6508)
- Tianhong Teng (ORCID: https://orcid.org/0000-0002-2393-3001)
- Xiaodong Gao (ORCID: https://orcid.org/0000-0003-0119-2334)
- Xiangfei Sun (ORCID: https://orcid.org/0000-0002-9808-2707)
- H Wang (ORCID: https://orcid.org/0000-0003-3091-5343)
- Xiao-Jun Lin (ORCID: https://orcid.org/0000-0002-5015-330X)
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Shanghai Cancer Institute (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1404
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00