Performance of novel onchocerciasis rapid diagnostic tests in a field setting in South Sudan
O. volvulus and Mansonella spp. prevalence was high among pregnant and post-partum women in Maridi. The novel RDTs demonstrated sensitivities within the range of the commercially available Ov16 SD Bioline RDT, meeting the WHO threshold for onchocerciasis mapping but not for MDA stopping decisions. No RDT met the specificity threshold of 99.8%, although some exhibited slightly higher specificity than Ov16 SD Bioline RDT. This suboptimal specificity raises concerns, underscoring the need for better diagnostic tools to support onchocerciasis elimination efforts.
Authors
- Chiara Trevisan (ORCID: https://orcid.org/0000-0002-4920-6750)
- Yak Yak Bol (ORCID: https://orcid.org/0009-0008-1117-8943)
- Amber Hadermann (ORCID: https://orcid.org/0000-0003-1207-5811)
- Luís‐Jorge Amaral (ORCID: https://orcid.org/0000-0001-8155-9014)
- Joseph Nelson Siewe Fodjo (ORCID: https://orcid.org/0000-0003-3544-1239)
- Marina Saleeb (ORCID: https://orcid.org/0000-0002-8576-3554)
- Stephen Raimon Jada (ORCID: https://orcid.org/0000-0001-9208-3955)
- Abdu Seid (ORCID: https://orcid.org/0000-0001-8860-9846)
- Katja Polman
- Charlotte Lubbers
- Robert Colebunders (ORCID: https://orcid.org/0009-0006-0691-3697)
Institutions
- University of Antwerp (BE)
- University of Juba (SS)
- Liverpool School of Tropical Medicine (GB)
- Federal Ministry of Health (SD)
- Instituut voor Tropische Geneeskunde (BE)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1371/journal.pntd.0013736
- Citations
- 1
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40