Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study
Women with S. haematobium infection and those with recent parasitological clearance were found to have cervical gene alterations that have been reported in various cancers. Our findings suggest a possible increase in cervical cancer risk and susceptibility to secondary infections shortly after treatment. Further research is necessary to ascertain whether altered gene expression after parasitological clearance of S. haematobium resolves over time.
Authors
- Sheridan F. Bowers (ORCID: https://orcid.org/0000-0002-1818-726X)
- Saidi Kapiga (ORCID: https://orcid.org/0000-0003-1753-4060)
- Jennifer A. Downs (ORCID: https://orcid.org/0000-0001-9537-204X)
- Myung Hee Lee
- Daniëlle de Jong (ORCID: https://orcid.org/0000-0003-4003-5593)
- Govert J. van Dam (ORCID: https://orcid.org/0000-0003-3773-0819)
- Anna Mertelsmann (ORCID: https://orcid.org/0000-0003-4448-0600)
- Jane K. Maganga (ORCID: https://orcid.org/0000-0001-7806-9786)
- John Changalucha (ORCID: https://orcid.org/0000-0002-1248-9515)
- Adrian Y. Tan (ORCID: https://orcid.org/0000-0001-6969-6606)
- Kathryn Dupnik (ORCID: https://orcid.org/0000-0001-7100-2917)
- Humphrey D. Mazigo (ORCID: https://orcid.org/0000-0001-5219-6234)
- Paul L.A.M. Corstjens
- Maureen Ward
- Loyce Mhango
Institutions
- University of Zurich (CH)
- Cornell University (US)
- Catholic University of Health and Allied Sciences (TZ)
- Leiden University Medical Center (NL)
- London School of Hygiene & Tropical Medicine (GB)
- University Hospital of Zurich (CH)
- Center for Global Health (US)
- Mwanza Intervention Trials Unit (TZ)
- Bugando Medical Centre (TZ)
- National Institute for Medical Research (TZ)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1371/journal.pntd.0013569
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00