Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer
Increased polyamine synthesis is a prominent metabolic change induced by the androgen receptor that drives tumor progression and confers a targetable vulnerability in advanced prostate cancer. See related commentary by Alizadeh-Ghodsi and Goldstein, p. 1095.
Authors
- Samuel Ray Denmeade (ORCID: https://orcid.org/0000-0001-5442-515X)
- Srushti Kittane (ORCID: https://orcid.org/0000-0001-8776-2195)
- Samuel B. Warner (ORCID: https://orcid.org/0000-0002-1173-1998)
- Rajendra Kumar (ORCID: https://orcid.org/0000-0002-2845-8115)
- Elizabeth A. Thompson (ORCID: https://orcid.org/0000-0001-8464-9904)
- W. Nathaniel Brennen (ORCID: https://orcid.org/0000-0001-9807-7433)
- Elizabeth Penner (ORCID: https://orcid.org/0009-0009-4325-1911)
- Petya Apostolova (ORCID: https://orcid.org/0000-0002-3856-5109)
- John T. Isaacs (ORCID: https://orcid.org/0000-0002-3854-4658)
- Laura A. Sena (ORCID: https://orcid.org/0000-0001-6724-9546)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-2126-6778)
- Cassandra E. Holbert (ORCID: https://orcid.org/0000-0002-4869-1301)
- David E. Sanin (ORCID: https://orcid.org/0000-0003-0188-7267)
- Erika L. Pearce (ORCID: https://orcid.org/0000-0001-5592-5439)
- Sheila Jonnatan (ORCID: https://orcid.org/0000-0003-0278-2475)
- Susan L. Dalrymple (ORCID: https://orcid.org/0000-0003-1330-1964)
- Chi V. Dang (ORCID: https://orcid.org/0000-0002-4031-2522)
- Tracy Murray Stewart (ORCID: https://orcid.org/0000-0001-8679-6414)
- Robert A. Casero (ORCID: https://orcid.org/0000-0001-5653-3306)
- Jackson R. Foley (ORCID: https://orcid.org/0000-0002-4383-9522)
- Eneda Toska (ORCID: https://orcid.org/0000-0002-8974-9792)
- Angelo M. De Marzo (ORCID: https://orcid.org/0000-0003-4847-5307)
- Varsha Vakkala (ORCID: https://orcid.org/0009-0001-3674-0604)
- Dina Rosen (ORCID: https://orcid.org/0009-0008-4191-8754)
- Ashley Nwafor (ORCID: https://orcid.org/0009-0001-5663-8199)
- S.K.S.R. Kumar (ORCID: https://orcid.org/0009-0003-5679-0435)
- Anoushka Kadam (ORCID: https://orcid.org/0009-0006-0042-1341)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins University Applied Physics Laboratory (US)
- Johns Hopkins Hospital (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1532
- Citations
- 1
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81