Inhibition of NF-κB pathways alleviates hydrocephalus via modulation of choroid plexus epithelium inflammation in a rat intraventricular hemorrhage model
NF-κB activation post-IVH drives CPEs inflammation, increases CSF production, and contributes to hydrocephalus formation. Targeting the NF-κB pathway offers a promising strategy for the treatment of PHH.
Authors
- Yikai Yuan
- Junwen Guan (ORCID: https://orcid.org/0000-0002-4028-797X)
- Tong Sun (ORCID: https://orcid.org/0000-0002-4322-4376)
- Chao You (ORCID: https://orcid.org/0000-0002-9489-6084)
- Yicheng Zhou
- Ke Wu (ORCID: https://orcid.org/0000-0002-2860-1110)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Shanghai Liangyou (China) (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1371/journal.pone.0336346
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91