Olfactory Receptor Gene Deletions: A Novel Genetic Findings in Idiopathic Prepubertal Gynecomastia and Juvenile Macromastia
Although estrogen-gene CNVs were not detected, the OR4P4-OR4S2-OR4C6 deletion may represent an under-recognized genomic contributor to idiopathic PG and JM. Prospective studies with tissue-level validation and functional assays are needed to confirm clinical significance and clarify mechanism.
Authors
- Şükran Poyrazoğlu (ORCID: https://orcid.org/0000-0001-6806-9678)
- Firdevs Baş (ORCID: https://orcid.org/0000-0001-9689-4464)
- Adam Najaflı
- Zehra Oya Uyguner (ORCID: https://orcid.org/0000-0002-2035-4338)
- Güven Toksoy (ORCID: https://orcid.org/0000-0002-8103-9980)
- Birsen Karaman (ORCID: https://orcid.org/0000-0001-8640-0176)
- Feyza Darendelıler (ORCID: https://orcid.org/0000-0003-4786-0780)
- Aslı Derya Kardelen (ORCID: https://orcid.org/0000-0003-0594-8741)
- Somayyeh Heidargholizadeh
- Melek Yıldız (ORCID: https://orcid.org/0000-0002-6603-2983)
- Cansu Koç (ORCID: https://orcid.org/0000-0002-6097-5585)
- Seher Basaran
Institutions
- Istanbul University (TR)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1159/000549625
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00