The impact of pathological fluctuations versus biological variation on the interpretation of laboratory values
Differences between variational estimates that only account for healthy states (II-BV) and those that consider healthy and unhealthy states (IP-BV + PV) vary widely among biomarkers, highlighting the differential impact of PV on their interpretation. For biomarkers where IP is high, the RI may be useful to identify unhealthy individuals.
Authors
- Ariel I. Mundo (ORCID: https://orcid.org/0000-0002-6014-4538)
- Jean C. Emond (ORCID: https://orcid.org/0000-0003-1642-9242)
- Sahar Saeed (ORCID: https://orcid.org/0000-0002-0224-379X)
- Pierre‐Olivier Hétu
- Robert Goulden (ORCID: https://orcid.org/0000-0002-6912-2255)
- Quôc Dinh Nguyên (ORCID: https://orcid.org/0000-0001-5412-2597)
- Philippe Desmarais (ORCID: https://orcid.org/0000-0002-7516-9594)
- François Larivière
- Vincent Cheung
Institutions
- Queen's University (CA)
- McGill University Health Centre (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Practical Laboratory Medicine
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.plabm.2025.e00511
- Primary Topic
- Clinical Laboratory Practices and Quality Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00