Impact of pharmacist-led patient-centric care on hypothyroid patients with metabolic syndrome: A comprehensive care based interventional study

<h2>Abstract</h2><h3>Background</h3> Thyroid hormones play a pivotal role in regulating metabolism. Patient-centric care is needed for the effective management of hypothyroidism with comorbid cardiometabolic illnesses. <h3>Objectives</h3> To assess the impact of pharmacist-led comprehensive care on hypothyroid Patients with metabolic syndrome. <h3>Methods</h3> A randomized controlled study was conducted in the General Medicine Department of a tertiary care hospital with 200 hypothyroid patients with metabolic syndrome for a duration of 3 years. The study had two groups, a control group (received usual care from the treating physician) and an intervention group (received pharmaceutical care from an academic pharmacist along with the usual care). The provided pharmaceutical care includes patient education, medical and medication reconciliation, medication review, continued monitoring, identification and resolution of drug related problems and follow-up. The study parameters considered were thyroid hormones, metabolic components, symptoms, medication adherence, economic parameters and quality of life. The collected data were statistically analysed with SPSS ver.29. <h3>Results</h3> After providing pharmaceutical care in the intervention group, significant improvements were observed in the medication adherence pattern (p:0.01), which in turn resulted in normalizing thyroid hormones (TSH, T3, T4) and metabolic components. This enhanced clinical outcomes and improved quality of life. The pharmaceutical care provided was beneficial for the patients and cost-effective. <h3>Conclusions</h3> Pharmacist-led interdisciplinary care was effective in managing hypothyroidism and related metabolic complications. Comparable patient focussed care practices should be implemented in general and specialized endocrine clinics to enhance the therapy outcomes and quality of life.