Gamma-aminobutyric acid A receptor alpha 4 in the nucleus accumbens mediates cue-induced heroin-seeking behavior in male rats via miR-7b
MiR-7b suppression and GABRA4 upregulation form a feedback loop promoting cue-induced heroin-seeking reinstatement. These findings identify a compensatory miR-7b/GABRA4 axis in the NAc that counteracts relapse vulnerability, proposing novel targets for addiction intervention.
Authors
- Wei‐Sheng Chen (ORCID: https://orcid.org/0000-0001-8672-180X)
- Xiaohu Xie (ORCID: https://orcid.org/0000-0002-0100-6370)
- Wenhua Zhou (ORCID: https://orcid.org/0000-0002-4804-7559)
- Huifen Liu (ORCID: https://orcid.org/0000-0003-2559-3466)
- Wenjin Xu (ORCID: https://orcid.org/0000-0001-6445-478X)
- Miaojun Lai
- Dan Fu (ORCID: https://orcid.org/0000-0001-6026-3601)
- Qingxiao Hong
- Zi Lin
- Tingting Wu
- Zemin Xu
Institutions
- Ningbo Kangning Hospital (CN)
- Ningbo College of Health Sciences (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1097/wnr.0000000000002225
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00