PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects
This study developed a high-throughput luciferase-based PPARγ-responsive cellular model to screen chemicals that may contribute to PF through the inhibition of PPARγ activity. The model demonstrates potential as a useful tool for preliminary chemical evaluation. These results suggest a possible role of PPARγ-mediated mechanisms in the development of PF. This work may provide a foundational framework for future efforts in hazard screening and drug discovery aimed at mitigating the effects of PF.
Authors
- Shengran Wang
- Stephan Lang (ORCID: https://orcid.org/0009-0000-4420-9664)
- Yang Chen (ORCID: https://orcid.org/0000-0003-0206-1889)
- Xianli Du
- Zhenghao Bao
- Jun Yang (ORCID: https://orcid.org/0000-0003-1279-5560)
- Yangyang Sun (ORCID: https://orcid.org/0000-0002-4357-611X)
- Weidong Li (ORCID: https://orcid.org/0000-0003-0521-7412)
- Xueyang Lin
- Yuan Luo (ORCID: https://orcid.org/0000-0003-3153-7495)
- Yufeng Yang (ORCID: https://orcid.org/0000-0002-6128-1681)
- Weiqiang Sun (ORCID: https://orcid.org/0000-0003-4191-1129)
- Yongan Wang (ORCID: https://orcid.org/0000-0003-4939-7048)
- Yi Yang (ORCID: https://orcid.org/0000-0002-0045-215X)
- Xin Sui (ORCID: https://orcid.org/0000-0001-5716-045X)
- Ziqi Cui (ORCID: https://orcid.org/0009-0008-8572-5954)
- Weijie Yang
- Wenya Feng
Institutions
- Qingdao University (CN)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119433
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00