Comprehensive fecal metagenomic and metabolomic analysis reveals the role of gut microbiota and metabolites in detecting brain metastasis of small cell lung cancer
Compared to patients without distant metastasis, SCLC patients with BM exhibit distinctive gut microbial and metabolite profiles. These findings suggest that specific gut microbes and their metabolic products may serve as valuable biomarkers for diagnosing and stratifying treatment in brain metastatic SCLC.
Authors
- Xu Han (ORCID: https://orcid.org/0000-0001-7915-8609)
- Qiang Sun (ORCID: https://orcid.org/0000-0002-9516-4598)
- Jun Chen (ORCID: https://orcid.org/0000-0001-7447-1815)
- Dan Zang
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1673983
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00