Altered homotopic functional connectivity in primary angle-closure glaucoma correlates with cell-type–specific neurotransmitter and gene expression transcriptional signatures: a functional MRI study

Together, these findings suggest that interhemispheric dysconnectivity in PACG is not only a reflection of functional brain changes but is also grounded in molecular and cellular mechanisms. This integrative approach advances our understanding of PACG as a brain-wide neurodegenerative condition and offers new perspectives for targeting glial, vascular, and neuromodulatory pathways in future therapeutic interventions.