Medical Management and Revascularization for Asymptomatic Carotid Stenosis
Among patients with high-grade stenosis without recent symptoms, the addition of stenting led to a lower risk of a composite of perioperative stroke or death or ipsilateral stroke within 4 years than intensive medical management alone. Carotid endarterectomy did not lead to a significant benefit. (Funded by the National Institute of Neurological Disorders and Stroke and others; CREST-2 ClinicalTrials.gov number, NCT02089217.).
Authors
- Malcolm Foster (ORCID: https://orcid.org/0009-0005-9109-9118)
- Wayne M. Clark (ORCID: https://orcid.org/0000-0001-7901-5659)
- Seemant Chaturvedi (ORCID: https://orcid.org/0000-0001-8660-7644)
- Vaqar Ali
- Navdeep Sangha (ORCID: https://orcid.org/0000-0001-9650-0488)
- Thomas G. Brott (ORCID: https://orcid.org/0000-0002-1266-0941)
- Philip Teal (ORCID: https://orcid.org/0000-0002-6548-382X)
- Gary S. Roubin (ORCID: https://orcid.org/0000-0002-3246-9239)
- Robert D. Ecker
- Curtis A. Given
- Jenifer H. Voeks (ORCID: https://orcid.org/0000-0002-5544-3322)
- James F. Meschia (ORCID: https://orcid.org/0000-0002-4475-8142)
- Ariane Mackey (ORCID: https://orcid.org/0000-0002-6916-9328)
- Tanya N. Turan (ORCID: https://orcid.org/0000-0001-5399-8845)
- Kevin M. Barrett (ORCID: https://orcid.org/0009-0005-2912-5821)
- John Huston (ORCID: https://orcid.org/0000-0003-0584-9460)
- Bart M. Demaerschalk (ORCID: https://orcid.org/0000-0001-7262-817X)
- James D Rhodes (ORCID: https://orcid.org/0000-0002-2307-0904)
- Brajesh K. Lal (ORCID: https://orcid.org/0000-0001-6724-8201)
- Vikram S. Kashyap (ORCID: https://orcid.org/0000-0003-1780-979X)
- Joseph H. Rapp
- Mark R. Harrigan (ORCID: https://orcid.org/0000-0002-8258-6150)
- Dipankar Mukherjee (ORCID: https://orcid.org/0000-0001-5280-6303)
- Carlos Mena‐Hurtado (ORCID: https://orcid.org/0000-0002-4954-5672)
- Fayaz A. Shawl
- W. Charles Sternbergh
- Giuseppe Lanzino
- Herbert D. Aronow (ORCID: https://orcid.org/0000-0002-9061-7893)
- Lloyd J. Edwards (ORCID: https://orcid.org/0000-0002-7788-4575)
- Virginia J. Howard (ORCID: https://orcid.org/0000-0003-4912-9975)
- Matthew C. Koopmann (ORCID: https://orcid.org/0000-0002-3551-797X)
- Virginia G. Wadley (ORCID: https://orcid.org/0000-0003-4524-8395)
- Randolph S. Marshall (ORCID: https://orcid.org/0000-0003-3037-0283)
- George Howard (ORCID: https://orcid.org/0000-0002-3068-5720)
- Ronald M. Lazar (ORCID: https://orcid.org/0000-0002-7388-042X)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9122-8067)
- Michael Jones (ORCID: https://orcid.org/0000-0001-9118-755X)
- Robert D. Brown (ORCID: https://orcid.org/0000-0002-7065-8807)
- Ángel Chamorro (ORCID: https://orcid.org/0000-0002-0392-6285)
- Laura Llull (ORCID: https://orcid.org/0000-0001-6897-2277)
- Scott Silverman
- Wesley S. Moore
- Hoang S. Tran (ORCID: https://orcid.org/0009-0008-9940-8685)
- Donald Heck
Institutions
- University of Maryland, Baltimore (US)
- Deaconess Hospital (US)
- Van Andel Institute (US)
- Ochsner Health System (US)
- Medical University of South Carolina (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- Inova Fairfax Hospital (US)
- University of Tennessee Medical Center (US)
- Novant Health (US)
- WinnMed (US)
- Vancouver General Hospital (CA)
- Henry Ford Hospital (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Centre hospitalier universitaire de Québec (CA)
- Central Baptist Hospital (US)
- MaineHealth (US)
- Centre for Research in Engineering Surface Technology (IE)
- Hospital Clínic de Barcelona (ES)
- Mayo Clinic in Arizona (US)
- Kaiser Permanente West Los Angeles Medical Center (US)
- First Coast Cardiovascular Institute (US)
- Mayo Clinic in Florida (US)
- Muslim Community Center Medical Clinic (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1056/nejmoa2508800
- Citations
- 33
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 50.11