Medical Management and Revascularization for Asymptomatic Carotid Stenosis

Among patients with high-grade stenosis without recent symptoms, the addition of stenting led to a lower risk of a composite of perioperative stroke or death or ipsilateral stroke within 4 years than intensive medical management alone. Carotid endarterectomy did not lead to a significant benefit. (Funded by the National Institute of Neurological Disorders and Stroke and others; CREST-2 ClinicalTrials.gov number, NCT02089217.).

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Institutions

Publication Details

Journal
New England Journal of Medicine
Published
2025-11-21
DOI
https://doi.org/10.1056/nejmoa2508800
Citations
33
Primary Topic
Cerebrovascular and Carotid Artery Diseases
Type
article
Field-Weighted Citation Impact
50.11
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article

Medical Management and Revascularization for Asymptomatic Carotid Stenosis

Malcolm Foster, Wayne M. Clark, Seemant Chaturvedi, Vaqar Ali et al.
33 citations
New England Journal of Medicine
Cerebrovascular and Carotid Artery Diseases
50.11
article

Medical Management and Revascularization for Asymptomatic Carotid Stenosis

Malcolm Foster, Wayne M. Clark, Seemant Chaturvedi, Vaqar Ali, Navdeep Sangha, Thomas G. Brott, Philip Teal, Gary S. Roubin, Robert D. Ecker, Curtis A. Given, Jenifer H. Voeks, James F. Meschia, Ariane Mackey, Tanya N. Turan, Kevin M. Barrett, John Huston, Bart M. Demaerschalk, James D Rhodes, Brajesh K. Lal, Vikram S. Kashyap, Joseph H. Rapp, Mark R. Harrigan, Dipankar Mukherjee, Carlos Mena‐Hurtado, Fayaz A. Shawl, W. Charles Sternbergh, Giuseppe Lanzino, Herbert D. Aronow, Lloyd J. Edwards, Virginia J. Howard, Matthew C. Koopmann, Virginia G. Wadley, Randolph S. Marshall, George Howard, Ronald M. Lazar, Yu Zhang, Michael Jones, Robert D. Brown, Ángel Chamorro, Laura Llull, Scott Silverman, Wesley S. Moore, Hoang S. Tran, Donald Heck
article en
33 citations

Abstract

Among patients with high-grade stenosis without recent symptoms, the addition of stenting led to a lower risk of a composite of perioperative stroke or death or ipsilateral stroke within 4 years than intensive medical management alone. Carotid endarterectomy did not lead to a significant benefit. (Funded by the National Institute of Neurological Disorders and Stroke and others; CREST-2 ClinicalTrials.gov number, NCT02089217.).

New England Journal of MedicineVol. 394(3)
University of Maryland, Baltimore (US), Deaconess Hospital (US), Van Andel Institute (US), Ochsner Health System (US), Medical University of South Carolina (US), University of California, Los Angeles (US), Oregon Health & Science University (US), University of California, San Francisco (US), Columbia University Irving Medical Center (US), Inova Fairfax Hospital (US), University of Tennessee Medical Center (US), Novant Health (US), WinnMed (US), Vancouver General Hospital (CA), Henry Ford Hospital (US), University of Alabama at Birmingham (US), Yale University (US), Massachusetts General Hospital (US), Centre hospitalier universitaire de Québec (CA), Central Baptist Hospital (US), MaineHealth (US), Centre for Research in Engineering Surface Technology (IE), Hospital Clínic de Barcelona (ES), Mayo Clinic in Arizona (US), Kaiser Permanente West Los Angeles Medical Center (US), First Coast Cardiovascular Institute (US), Mayo Clinic in Florida (US), Muslim Community Center Medical Clinic (US), University of Tennessee at Knoxville (US)
Openalex Percentile: Top 0%
Cerebrovascular and Carotid Artery Diseases
50.11
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