High <i>MDR1</i> expression in RA is associated with increased MMP-3 levels and use of bDMARDs: potential independence of JAK inhibitors from <i>MDR1</i>
High MDR1 expression correlates with elevated MMP-3 levels and more frequent bDMARDs use. JAK inhibitors remain effective regardless of MDR1 status, potentially bypassing MDR1-mediated cellular drug resistance in RA.
Authors
- Tsukasa Matsubara (ORCID: https://orcid.org/0000-0002-3342-3419)
- Yuichi Kuroda (ORCID: https://orcid.org/0000-0003-2196-4610)
- Tomoyuki Matsumoto (ORCID: https://orcid.org/0000-0003-4587-0029)
- Ken Tsumiyama
- Ryosuke Kuroda (ORCID: https://orcid.org/0000-0001-5097-7264)
- Kenichi Kikuchi (ORCID: https://orcid.org/0000-0002-6235-3990)
- Yuma Onoi (ORCID: https://orcid.org/0000-0002-0624-508X)
- Masanori Tsubosaka (ORCID: https://orcid.org/0000-0001-6702-1242)
- Tomoyuki Kamenaga (ORCID: https://orcid.org/0000-0001-6191-674X)
- Naoki Nakano (ORCID: https://orcid.org/0000-0003-4067-9233)
Institutions
- Matsubara Mayflower Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/rheumatology/keaf622
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05