Alzheimer Disease Blood Biomarker Concentrations Across Race and Ethnicity Groups in Middle-Aged Adults
In this cohort of middle-aged adults, the use of appropriate statistical estimation to ensure population representation indicated that blood-based AD biomarker concentrations were not distinguishable among race and ethnicity groups. Common medical conditions were associated with plasma biomarker concentrations similarly across race and ethnicity groups. These results highlight the importance of considering population representation and comorbid conditions in AD research to ensure accurate characterization of disease pathophysiology and improve precision of diagnostic and treatment strategies for populations that experience AD disparities.
Authors
- Eric Grodsky (ORCID: https://orcid.org/0000-0003-2178-0803)
- Chandra Muller (ORCID: https://orcid.org/0000-0002-2216-7034)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Michael J. Culbertson (ORCID: https://orcid.org/0000-0001-6883-9767)
- Soobin Kim (ORCID: https://orcid.org/0000-0002-7909-1608)
- John Robert Warren (ORCID: https://orcid.org/0000-0001-6079-5122)
- Bharat Thyagarajan (ORCID: https://orcid.org/0000-0001-6968-6985)
- Jennifer J. Manly (ORCID: https://orcid.org/0000-0002-9481-7497)
Institutions
- University of Minnesota (US)
- University of Wisconsin–Madison (US)
- Columbia University (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.45046
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute