Sex differences in beneficial and pathogenic bacteria in People With HIV (PWH) with a history of heavy alcohol drinking
Overall, we observed significant sex-based differences in the relative abundances of beneficial bacterial communities such as butyrate producers and potential pathogenic Prevotella community in the gut microbiome of PWH with a history of heavy alcohol consumption. The observed sex-based differences are clinically relevant and could inform therapeutic strategies with evidence-based probiotics.
Authors
- Smita S. Ghare (ORCID: https://orcid.org/0009-0005-9627-4843)
- Dmitry A. Lioznov (ORCID: https://orcid.org/0000-0003-3643-7354)
- Aakarsha V. Rao (ORCID: https://orcid.org/0009-0001-7149-2562)
- Craig J. McClain (ORCID: https://orcid.org/0000-0002-7219-8939)
- Shirish Barve (ORCID: https://orcid.org/0009-0008-7833-527X)
- Evgeny Krupitsky (ORCID: https://orcid.org/0000-0002-0529-4525)
- Elena Blokhina (ORCID: https://orcid.org/0000-0001-5811-9897)
- Matthew S. Freiberg (ORCID: https://orcid.org/0000-0002-3699-4022)
- Joseph F. Petrosino (ORCID: https://orcid.org/0000-0002-4046-6898)
- Edwin Zvartau (ORCID: https://orcid.org/0000-0002-3597-7482)
- Gregory Patts (ORCID: https://orcid.org/0000-0001-5539-6813)
- Jeffrey H. Samet (ORCID: https://orcid.org/0000-0002-0897-3400)
- Debbie M. Cheng (ORCID: https://orcid.org/0000-0002-2206-3059)
- Hillary Tindle
- Kristi L. Hoffman (ORCID: https://orcid.org/0000-0002-4497-120X)
- Kaku So‐Armah (ORCID: https://orcid.org/0000-0003-1505-6384)
- Vasuk Gautam (ORCID: https://orcid.org/0000-0002-9204-1963)
Institutions
- Boston University (US)
- University of Louisville (US)
- Baylor College of Medicine (US)
- Vanderbilt University (US)
- Norton Healthcare (US)
- First Pavlov State Medical University of St. Petersburg (RU)
- St.Petersburg V.M.Bekhterev Psychoneurological Research Institute (RU)
- VA Tennessee Valley Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Louisville VA Medical Center (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1632949
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- University of Louisville
- National Institutes of Health