HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes
By focusing on RNA instead of DNA, we expand our understanding of the carcinogenic mechanisms of HPVint, in part addressing the conflicting findings of whether HPVint is associated with aggressive phenotypes and worse clinical consequences, and provide potential biomarkers to advance precision oncology in HPV-associated HNSCC. Newly identified genes with recurrent integration events may serve as candidates for targeted therapy.
Authors
- Nisha J. D’Silva (ORCID: https://orcid.org/0000-0001-7030-3187)
- Sarah Soppe (ORCID: https://orcid.org/0009-0000-2465-9377)
- Maureen A. Sartor (ORCID: https://orcid.org/0000-0001-6155-5702)
- Joshua D. Welch (ORCID: https://orcid.org/0000-0002-5869-2391)
- Tingting Qin (ORCID: https://orcid.org/0000-0003-3810-7578)
- Min Liu (ORCID: https://orcid.org/0000-0003-2768-0301)
- Aishani Kulshreshtha (ORCID: https://orcid.org/0009-0004-9487-3159)
- Maria Lawas (ORCID: https://orcid.org/0009-0002-3480-9484)
- Shiting Li (ORCID: https://orcid.org/0000-0002-9074-8957)
- Chamila D. Perera (ORCID: https://orcid.org/0000-0002-7115-618X)
- Bailey F. Garb (ORCID: https://orcid.org/0000-0002-9230-054X)
- Laura S. Rozek (ORCID: https://orcid.org/0000-0001-6731-7000)
- Chen Li (ORCID: https://orcid.org/0000-0002-1790-6664)
- Yvonne Xinyi Lim (ORCID: https://orcid.org/0000-0002-8070-2779)
- Shaomiao Xia (ORCID: https://orcid.org/0009-0004-0267-1673)
Institutions
- University of North Carolina at Chapel Hill (US)
- Georgetown University (US)
- University of Michigan (US)
- Michigan United (US)
- Michigan Center for Translational Pathology (US)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0645
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00