Does perioperative discontinuation of anti-rheumatic drugs increase postoperative complications in orthopedic surgery for rheumatoid arthritis?
In orthopedic surgery for patients with RA, maintaining the standard or the half of administration interval of bDMARD appears safe in the preoperative period. However, the drug discontinuation may increase the risk of postoperative flare-ups, particularly with IL-6 inhibitors. In addition, T-cell function modifiers may be associated with a lower risk of delayed wound healing, suggesting their safety profile in this context.
Authors
- Takumi Matsumoto (ORCID: https://orcid.org/0000-0003-2363-9803)
- Ryota Hara
- Tsukasa Matsubara (ORCID: https://orcid.org/0000-0002-3342-3419)
- Koji Sakuraba (ORCID: https://orcid.org/0000-0003-2171-614X)
- Katsuaki Kanbe (ORCID: https://orcid.org/0000-0002-0703-4938)
- Yuichi Mochida (ORCID: https://orcid.org/0000-0002-8414-0822)
- Hiromu Ito
- Atsushi Kaneko (ORCID: https://orcid.org/0000-0003-4392-912X)
- Kosuke Ebina (ORCID: https://orcid.org/0000-0002-2426-1024)
- Shigeyoshi Tsuji (ORCID: https://orcid.org/0000-0002-4172-8730)
- Ayako Kubota (ORCID: https://orcid.org/0000-0001-8814-169X)
- Natsuko Nakagawa
- Koichi Murata (ORCID: https://orcid.org/0000-0002-7896-3937)
- Toshihisa Kojima (ORCID: https://orcid.org/0000-0001-8497-0212)
- Hajime Ishikawa (ORCID: https://orcid.org/0000-0002-8325-4916)
- Takeshi Mochizuki (ORCID: https://orcid.org/0000-0002-8316-8671)
- Isao Matsushita (ORCID: https://orcid.org/0000-0002-5932-2616)
- Arata Nakajima (ORCID: https://orcid.org/0000-0003-1132-9226)
- Shigeki Momohara (ORCID: https://orcid.org/0000-0002-5954-0664)
- Masanori Nakayama (ORCID: https://orcid.org/0000-0002-6757-897X)
- Keiichiro Nishida (ORCID: https://orcid.org/0000-0003-3818-9657)
- Yukio Akasaki
Institutions
- Kanazawa University (JP)
- Toho University (JP)
- Kyushu University (JP)
- Kanazawa Medical University (JP)
- Kagawa University (JP)
- Kyoto University (JP)
- Yokohama City University Medical Center (JP)
- National Kyushu Medical Center (JP)
- Kurashiki Central Hospital (JP)
- Nagoya University Hospital (JP)
- Kanazawa Medical Center (JP)
- Toho University Omori Medical Center (JP)
- Okayama University Hospital (JP)
- Matsubara Mayflower Hospital (JP)
- Institute for Advanced Medical Research (US)
- Osaka Minami Medical Center (JP)
- Toho University Medical Center Sakura Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Tokyo Women's Medical University (JP)
- Scripps Clinic (US)
- Edogawa Hospital (JP)
- Nagoya Medical Center (JP)
- Nippon Medical School Hospital (JP)
- Nara Medical University (JP)
- The University of Tokyo (JP)
- International University of Health and Welfare (JP)
- Yokohama City University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s13075-025-03683-9
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Ono Pharmaceutical