Zinc binding to a conserved motif in STIM1 induces clustering and SOCE activation
Our results identify a zinc-binding module upstream of the EF-hand as a critical determinant of STIM1 activation. These findings provide new insights into the molecular interplay between zinc and calcium signaling and suggest a regulatory mechanism by which cellular zinc levels may influence ER calcium homeostasis.
Authors
- Marc Bartoli (ORCID: https://orcid.org/0000-0003-3339-9858)
- Géraldine Ferracci
- Andrey V. Golovin (ORCID: https://orcid.org/0000-0002-8908-4268)
- François Devred (ORCID: https://orcid.org/0000-0001-5990-8898)
- Viktoriia E. Baksheeva (ORCID: https://orcid.org/0000-0002-0445-2667)
- Claude Villard (ORCID: https://orcid.org/0000-0002-6600-0762)
- Philipp O. Tsvetkov (ORCID: https://orcid.org/0000-0002-8622-8836)
- Benedicte Alary
- Sébastien Courrier
- Sabrina Beaumier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Délégation Provence et Corse (FR)
- Centrale Méditerranée (FR)
- Physique des interactions ioniques et moléculaires (FR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12964-025-02499-z
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00