Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity
Our data place TNFR2 signaling as a potential upstream regulator of TOX expression in T cells and propose TNFR2 antagonism as a novel immunotherapeutic strategy.
Authors
- Sarah Cook (ORCID: https://orcid.org/0000-0002-0516-9388)
- Emily Lerner (ORCID: https://orcid.org/0000-0003-1597-8581)
- Peter E. Fecci (ORCID: https://orcid.org/0000-0002-2912-8695)
- Alexandra Miggelbrink (ORCID: https://orcid.org/0000-0003-1499-2269)
- Jessica Waibl Polania (ORCID: https://orcid.org/0000-0002-5204-8191)
- Aditya Mohan (ORCID: https://orcid.org/0000-0001-7614-9387)
- Andrew A. Hardigan (ORCID: https://orcid.org/0000-0003-1770-2757)
- Daniel Wilkinson (ORCID: https://orcid.org/0000-0001-9619-6914)
- Anoop P. Patel (ORCID: https://orcid.org/0000-0001-7078-9535)
- Selena Lorrey (ORCID: https://orcid.org/0000-0001-5567-2830)
- Kelly Hotchkiss (ORCID: https://orcid.org/0000-0001-9175-1579)
- Saskia Hemmers (ORCID: https://orcid.org/0000-0002-5575-0509)
- Katayoun Ayasoufi (ORCID: https://orcid.org/0000-0002-3797-0823)
- Lucas P. Wachsmuth (ORCID: https://orcid.org/0000-0002-2995-2983)
- Emily Blandford (ORCID: https://orcid.org/0009-0000-7440-3185)
Institutions
- Mayo Clinic (US)
- Duke University (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
- Pediatric Brain Tumor Foundation (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3455
- Citations
- 2
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Cancer Research Institute