Effects of canagliflozin combined with metformin therapy on insulin sensitivity in patients with type 2 diabetes mellitus

The combination of canagliflozin and metformin in the treatment of T2DM not only effectively reduces blood glucose levels but also significantly improves insulin sensitivity and pancreatic function, with good safety profiles. For T2DM patients with obesity or insulin resistance, the combination therapy may offer additional benefits in terms of weight management and enhanced insulin sensitivity.