Tumor exosomal miR-221-3p induces glycolysis through the LIFR/GLUT1 pathway to destroy the cerebral vascular endothelial cell barrier and promote breast cancer brain metastasis
Our findings indicate that BC can target LIFR in hCMEC/D3 cells via exosomal miR-221-3p, thereby promoting glycolysis and inhibiting the expression of tight junction proteins, which facilitates tumor metastasis.
Authors
- T Ye (ORCID: https://orcid.org/0000-0002-6643-726X)
- Shanyi Zhang
- Zhuojun Luo (ORCID: https://orcid.org/0000-0001-6634-4090)
- Wenkai Jiang (ORCID: https://orcid.org/0000-0002-2213-9850)
- Hongru Yao
- Jianping Zhou (ORCID: https://orcid.org/0000-0002-7483-3414)
- Shiwei Li (ORCID: https://orcid.org/0000-0002-0633-7873)
- Shuwen Wang (ORCID: https://orcid.org/0000-0002-3967-5756)
- Kaitao Zhu
- Tracey A. Martin
- Jilong Hei
Institutions
- Sun Yat-sen University (CN)
- University Health System (US)
- Sun Yat-sen Memorial Hospital (CN)
- People’s Hospital of Linqing (CN)
- Guangzhou Medical University Cancer Hospital (CN)
- Cardiff University (GB)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12967-025-07372-8
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84