Integrative analysis reveals SRD5A2 as a central mediator in PPCPs induced modulation of the prostate cancer immune microenvironment
The genes F2, SRD5A2, NEK2, and HGFAC play critical roles in PPCPs induced PCa progression, with SRD5A2 being particularly significant. These findings suggest that PPCPs may disrupt TIME homeostasis by downregulating SRD5A2 expression, thereby promoting immune evasion of PCa cells and accelerating tumor progression.
Authors
- Peng Ji (ORCID: https://orcid.org/0000-0002-4390-2114)
- Zhiqiang Zeng (ORCID: https://orcid.org/0000-0002-9533-3347)
- Chunyang Meng (ORCID: https://orcid.org/0000-0002-3334-9503)
- Tao Zhou (ORCID: https://orcid.org/0000-0003-1295-8331)
- Tao Li (ORCID: https://orcid.org/0000-0002-2681-0429)
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-6024-7836)
- Yuming Yang (ORCID: https://orcid.org/0000-0002-6702-2795)
- Yuqi Li (ORCID: https://orcid.org/0000-0003-4629-4027)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Mianyang 404 Hospital (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1007/s12672-025-03995-x
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52