High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation
To our knowledge, this study established a novel HFD-induced model of prepubertal obesity and central precocious puberty (CPP) in male rats. The findings suggest that obesity may accelerate pubertal onset, and that Smim20/PNX may participate in regulating pubertal development in males.
Authors
- Wei Qin (ORCID: https://orcid.org/0009-0000-5615-3151)
- Runqi Wang (ORCID: https://orcid.org/0000-0003-0800-3954)
- Dan Zeng (ORCID: https://orcid.org/0000-0002-3610-1618)
- Jingzi Zhong
- Dan Lan (ORCID: https://orcid.org/0000-0001-6281-0883)
- Tao Xie (ORCID: https://orcid.org/0009-0006-7118-0055)
- Shuting Chen
- Yanfei Chen (ORCID: https://orcid.org/0000-0002-2185-9303)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- First People's Hospital of Nanning (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fendo.2025.1711374
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi Medical University