Bioinformatic analysis and validation of candidate genes in the eutopic endometrium reveal differential expressions in diffuse adenomyosis, endometrioma, and their co-existence
Distinct expression profiles were observed in diffuse adenomyosis versus ovarian endometriosis and co-existent phenotype. Expression of key genes indicated enhanced ECM remodeling in adenomyosis, with MMP7, MMP9, and MMP11 emerging as potential discriminatory markers. The divergent expressions in the co-existent phenotype suggest distinct molecular mechanisms that merit further study.
Authors
- Ashutosh Sahu (ORCID: https://orcid.org/0000-0002-9289-2848)
- Koel Chaudhury (ORCID: https://orcid.org/0000-0001-8739-5110)
- Pratip Chakraborty (ORCID: https://orcid.org/0000-0001-5835-8214)
- Sanjukta Dasgupta (ORCID: https://orcid.org/0000-0002-9085-2658)
- Ratna Chattopadhyay
- Sunita Sharma (ORCID: https://orcid.org/0000-0002-2942-5227)
- Subhash Chandra Halder
- Imon Mitra
- Bishnupriya Saha
Institutions
- Techno India University (IN)
- Indian Institute of Technology Kharagpur (IN)
- Child In Need Institute (IN)
- Institute of Reproductive Medicine (IN)
- Bloom Fertility Centre (IN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s40001-025-03412-7
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Technology Kharagpur