Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery
Substantially increased public health benefits might be achieved by adding seasonally-targeted chemoprevention to current PMC in sub-perennial malaria transmission settings. Effectiveness-implementation studies will be crucial to generate empirical evidence of public health impact including on the disease burden averted, safety, and cost-effectiveness of the hybrid approach. Such studies should also explore determinants of implementation success including operational feasibility, coverage, and acceptability of proposed dosing strategies to inform deployment decisions.
Authors
- Swapnoleena Sen (ORCID: https://orcid.org/0000-0003-2150-4016)
- David M. Schellenberg (ORCID: https://orcid.org/0000-0001-8222-0186)
- Melissa A. Penny (ORCID: https://orcid.org/0000-0002-4972-593X)
Institutions
- Swiss Tropical and Public Health Institute (CH)
- The University of Western Australia (AU)
- University of Basel (CH)
- London School of Hygiene & Tropical Medicine (GB)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12936-025-05630-0
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Science Foundation
- Bill and Melinda Gates Foundation
- Universität Basel
- London School of Hygiene and Tropical Medicine
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Universität Zürich