Efficacy and Safety of the Ketamine-Dexmedetomidine Combination in Adult Sedation and Anesthesia: A Systematic Review and Single-Arm Meta-Analysis of Randomized Controlled Trials
In this single-arm synthesis, KD provides effective sedation and analgesia with stable vital signs and high satisfaction. Nonetheless, bradycardia, desaturation, and nausea remain clinically relevant and procedure-dependent, requiring careful patient selection and vigilant monitoring.
Authors
- Alfredo Berruti (ORCID: https://orcid.org/0000-0002-3956-0043)
- Emília Maria Matos Rocha
- Flávio W.F. Melo
- Rene Franco
- Rafael Victor Nunes Lima (ORCID: https://orcid.org/0000-0002-8003-5494)
- Paulo Salomão Bendazzoli
- Enrico B Brondi
Institutions
- Universidade Federal do Piauí (BR)
- Centro Universitário UNINOVAFAPI (BR)
- Faculdade São Leopoldo Mandic (BR)
- Universidade Federal do Maranhão (BR)
- Universidade Federal de Uberlândia (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-21
- DOI
- https://doi.org/10.7759/cureus.97432
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00