Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways
This study revealed that NSCLC cells acquire stemness traits through NF-κB activation, with p-DNA-PKcs-induced phosphorylation of p65 being a prerequisite for p65 acetylation and sustained NF-κB activation in drug-resistant cells. Targeting DNA-PKcs represents a novel and effective treatment strategy to overcome DDP resistance in NSCLC.
Authors
- Qiumei Li
- Mingshui Chen
- Chunjiang Liu (ORCID: https://orcid.org/0000-0002-4100-5145)
- Guibin Weng (ORCID: https://orcid.org/0009-0006-4427-8399)
- Ling Wang (ORCID: https://orcid.org/0009-0005-4954-4409)
- Wansong Lin (ORCID: https://orcid.org/0000-0002-4490-6133)
- Lingyu Zhang (ORCID: https://orcid.org/0000-0002-4501-8445)
- S. M. Wu
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Cancer Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12967-025-07282-9
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province