Cortical thickness signature as a predictor of diagnostic transition from major depressive disorder to bipolar disorder in late adolescence and early adulthood: a prospective nested case–control study
In this cross-diagnostic study focusing on late adolescence and early adulthood, we found evidence suggesting shared and disease-specific cortical thickness patterns of depressive episodes. Our study offers potential insights into the neuropathological mechanisms of mood disorders and may contribute to the early identification of BD from MDD.
Authors
- Haowen Zou
- Zhijian Yao (ORCID: https://orcid.org/0000-0001-6255-5771)
- Na Shen (ORCID: https://orcid.org/0000-0003-4362-9207)
- Rui Yan (ORCID: https://orcid.org/0000-0002-8495-1289)
- Qing Lü (ORCID: https://orcid.org/0000-0001-7717-391X)
- Shui Tian
- Yiwen Wang (ORCID: https://orcid.org/0000-0003-2337-1181)
- Jiabo Shi (ORCID: https://orcid.org/0000-0002-1714-5447)
- Zhilu Chen (ORCID: https://orcid.org/0000-0002-7165-7996)
- L Hua
- Xiaoqin Wang (ORCID: https://orcid.org/0000-0001-6845-0161)
- Ting Wang (ORCID: https://orcid.org/0000-0001-6355-800X)
- Xue Li (ORCID: https://orcid.org/0000-0002-8313-3671)
- Junling Sheng
- Hao Sun (ORCID: https://orcid.org/0009-0005-7151-0467)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Xuzhou Medical College (CN)
- Southeast University (BD)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Nanjing Brain Hospital (CN)
- Jiangsu Province Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12916-025-04466-4
- Citations
- 1
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province