Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases
Our study uncovered several immune-related drugs associated with increased breast cancer reporting in women with AIDs. This risk may be explained by several potential drug targets with causal roles, or by the shared genetic comorbidity between specific AIDs and breast cancer. These insights emphasize the need for tailored breast cancer surveillance and highlight potential molecular targets for intervention in vulnerable populations.
Authors
- Yang Kuan
- Zeyu Li (ORCID: https://orcid.org/0000-0003-3932-9244)
- Kejian Zhang (ORCID: https://orcid.org/0000-0001-6334-9697)
- Chongzhe Pei (ORCID: https://orcid.org/0000-0002-6105-2774)
- Ningning Song (ORCID: https://orcid.org/0000-0002-9294-0790)
- Xinquan Xi
Institutions
- Anhui Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12967-025-07338-w
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University