Immunomodulatory and regenerative effects of human umbilical cord MSC-EVs in Cutaneous Leishmaniasis
Our findings demonstrate that stimulation with hUCMSC-EVs enhanced Leishmania killing, inducing the upregulation of immune mediators. hUCMSC-EVs also promoted wound closure and keratinocyte migration. In vivo, intravenous injection of hUCMSC-EVs impaired lesion development, supporting their potential as an adjunctive therapy for CL. This study lays the groundwork for further investigation into MSC-EVs in host-directed therapies for infectious diseases.
Authors
- Zaquer Suzana Munhoz Costa‐Ferro (ORCID: https://orcid.org/0000-0002-9120-8856)
- S. Pires
- Erick Correia Loiola (ORCID: https://orcid.org/0000-0002-7926-795X)
- Cristian G. Torres (ORCID: https://orcid.org/0000-0003-0019-2404)
- Luciano de S. Santos (ORCID: https://orcid.org/0000-0002-1381-1342)
- Pedro B. Borba
- Joana Figueiredo (ORCID: https://orcid.org/0000-0002-1590-1974)
- Juliana Perrone Bezerra de Menezes (ORCID: https://orcid.org/0000-0002-9380-8839)
- Camila I. de Oliveira (ORCID: https://orcid.org/0000-0002-7868-5164)
- Maria Laura Costa (ORCID: https://orcid.org/0000-0001-8280-3234)
- Kátia Nunes da Silva
- Gisele Vieira Rocha (ORCID: https://orcid.org/0000-0001-6437-4536)
- Bruno Solano de Freitas Souza (ORCID: https://orcid.org/0000-0003-3771-0439)
- Yasmim Luz
Institutions
- D’Or Institute for Research and Education (BR)
- Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s13287-025-04759-8
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto D'Or de Pesquisa e Ensino
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Oswaldo Cruz