Linezolid Serum Concentration Variability Among Critically Ill Patients Based on Renal Function and Continuous Renal Replacement Therapy Administration
After standard-dosing administration, linezolid levels vary widely in critically ill patients. Renal function significantly affects pharmacokinetics: severe impairment increases overdose risk, while ARC may cause underdosing. Standard-dosing appears adequate in CRRT patients, with levels similar to moderate-impairment. Continuous infusion aids target attainment in normal or ARC patients but raises overdose risk in severe impairment. TDM-based personalized dosing seems crucial to optimize therapy and reduce toxicity or failure.
Authors
- Beatrice Brunoni (ORCID: https://orcid.org/0009-0002-3110-5967)
- Gianpaola Monti
- Francesco Scaglione (ORCID: https://orcid.org/0000-0002-8554-2401)
- Stefano Agliardi (ORCID: https://orcid.org/0000-0001-9765-5529)
- Romano Danesi
- Leonardo Baggio (ORCID: https://orcid.org/0009-0005-3993-0381)
- Arianna Pani (ORCID: https://orcid.org/0000-0001-6464-2596)
- Stefania Paccagnini
- Thomas Länger (ORCID: https://orcid.org/0000-0002-9725-8520)
- Greta Guarnieri (ORCID: https://orcid.org/0009-0001-4589-017X)
- Riccardo Giossi (ORCID: https://orcid.org/0000-0002-7352-9445)
- Roberto Fumagalli (ORCID: https://orcid.org/0000-0003-0398-1329)
- Matteo Laratta
- Gianluca Gazzaniga (ORCID: https://orcid.org/0000-0003-0648-3309)
- S Santambrogio
Institutions
- University of Milan (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- University of Milano-Bicocca (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3390/antibiotics14121188
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00