The impact of miR-221-3p modification by the m6A demethylase ALKBH5 on the inflammatory response in spinal tuberculosis and its diagnostic significance
miR-221-3p may serve as a potential diagnostic biomarker for STB. ALKBH5 upregulation promotes STB progression by inhibiting miR-221-3p maturation via m6A demethylation, which enhances the inflammatory response. Targeting the ALKBH5/miR-221-3p axis may offer a novel therapeutic approach for STB.
Authors
- Mengqi Zhu (ORCID: https://orcid.org/0000-0001-8059-2197)
- Ningkui Niu (ORCID: https://orcid.org/0000-0001-7343-8458)
- Jiong Wang (ORCID: https://orcid.org/0000-0003-2691-5105)
- Xiaohong Duan (ORCID: https://orcid.org/0000-0002-6747-1734)
- Lijun Feng
- Linan Wang (ORCID: https://orcid.org/0000-0001-7766-8947)
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s13018-025-06473-w
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China