Cortical hypertrophy of the contralateral hemisphere after hemispherotomy in children with Sturge–Weber syndrome: A longitudinal volumetric study
This study demonstrates that the contralateral hemisphere undergoes time-dependent hypertrophy following hemispherotomy in patients with SWS. Early hemispherotomy may enhance this structural plasticity and contribute to improved neurodevelopmental outcomes. Longitudinal volumetric analysis of the contralateral hemisphere may serve as a surrogate biomarker of structural reorganization and a valuable tool to guide the optimal timing of surgical intervention in this population.
Authors
- Yasushi Iimura (ORCID: https://orcid.org/0000-0003-4263-5920)
- Kazuki Nomura
- Takumi Mitsuhashi (ORCID: https://orcid.org/0000-0001-8156-5385)
- Shimpei Abe
- Mika Nakazawa
- Hidenori Sugano (ORCID: https://orcid.org/0000-0002-7836-6585)
- Takato Akiba (ORCID: https://orcid.org/0009-0002-8507-2558)
- Hiroharu Suzuki (ORCID: https://orcid.org/0000-0002-9244-8472)
- Akihide Kondo (ORCID: https://orcid.org/0000-0003-1729-4490)
- Shino Shimada (ORCID: https://orcid.org/0000-0001-5525-7362)
- Kazuki Nishioka
- Ayuko Igarashi (ORCID: https://orcid.org/0000-0001-7130-937X)
- Tetsuya Ueda (ORCID: https://orcid.org/0000-0002-6062-3985)
- Mitsuru Ikeno (ORCID: https://orcid.org/0000-0003-2992-1834)
- Shimpei Matsuda
Institutions
- Juntendo University (JP)
- Minamiaoyama Eye Clinic (JP)
- Juntendo University Hospital (JP)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1111/epi.70029
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00