Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson’s disease: a proof-of-concept study
Bilateral iTBS targeting the leg representation of the primary motor cortex can potentiate AOIT effects in early-stage PIGD by enhancing cortical plasticity and motor learning. These findings support the integration of iTBS as a priming strategy within cognitive-motor rehabilitation protocols for PD. Trial registration Chinese Clinical Trial Registry, ChiCTR2300067657. Registered January 17, 2023.
Authors
- Xiaodong Zhu (ORCID: https://orcid.org/0000-0002-6535-4606)
- Dong Ming (ORCID: https://orcid.org/0000-0002-8192-2538)
- Jun Ma (ORCID: https://orcid.org/0000-0001-6232-1254)
- Xiaofei Zhang (ORCID: https://orcid.org/0000-0003-1610-5870)
- Lin Meng (ORCID: https://orcid.org/0000-0001-9787-9936)
- Deyu Wang (ORCID: https://orcid.org/0009-0008-2545-2595)
- Yu Shi (ORCID: https://orcid.org/0009-0001-1544-2042)
- Xiaoqi Zhao
- Hongbo Zhao (ORCID: https://orcid.org/0009-0001-5266-1965)
Institutions
- Tianjin University (CN)
- Tianjin Medical University General Hospital (CN)
- Xiyuan Hospital (CN)
- Human Computer Interaction (Switzerland) (CH)
- China Academy of Chinese Medical Sciences (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of NeuroEngineering and Rehabilitation
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12984-025-01789-4
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China