The association between multimorbidity and intrinsic capacity decline among older adults: the mediating role of frailty
This study first found frailty as partially mediating the multimorbidity-IC decline relationship, explaining 27.5% of the effect. The results underscore the necessity of integrated multimorbidity and frailty management to prevent and delay IC decline in older adults.
Authors
- Jiaqin Wang (ORCID: https://orcid.org/0000-0002-4581-0248)
- Emma Zhao (ORCID: https://orcid.org/0000-0001-7996-0618)
- Lulu Xiao (ORCID: https://orcid.org/0009-0005-9937-8381)
- Zhe Jin (ORCID: https://orcid.org/0000-0001-7911-7970)
- Junzi Dong (ORCID: https://orcid.org/0000-0002-0382-1141)
- Junyan Zeng (ORCID: https://orcid.org/0000-0002-2320-6357)
- Yan Dong
- Na Hu (ORCID: https://orcid.org/0000-0001-6362-0969)
- Qing Xu
- Yiying Yang (ORCID: https://orcid.org/0000-0001-7755-7956)
- Zhen Wu (ORCID: https://orcid.org/0000-0002-4985-4889)
- Hong Shi (ORCID: https://orcid.org/0000-0003-3776-498X)
- Linlin Hu (ORCID: https://orcid.org/0000-0001-6213-8732)
Institutions
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chengdu Medical College (CN)
- Jiangsu Ocean University (CN)
- Beijing Geriatric Hospital (CN)
- Lianyungang Oriental Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Beijing Haidian Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Public Health
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12889-025-25500-3
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.00