SETD3 regulates Bcl-6 expression and Tfh differentiation in SLE CD4+ T cells by manipulating histone methylation and acetylation
Elevated SETD3 expression in SLE CD4<sup>+</sup> T cells recruits NSD3, SMYD2, p300, and CBP to the Bcl-6 promoter, thus upregulating histone H3K4/K36 methylation and H3K9/K14 acetylation at this locus, which mediates the upregulation of Bcl-6 expression.
Authors
- Liang Hu (ORCID: https://orcid.org/0000-0001-6984-834X)
- Yu Rao (ORCID: https://orcid.org/0009-0001-0783-9154)
- Shu Ding (ORCID: https://orcid.org/0000-0002-7078-108X)
- Shengjie Xue (ORCID: https://orcid.org/0000-0001-9298-9124)
- Jieyue Liao
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s13148-025-02008-6
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China