Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure
Ocular overexposure to corticosteroids may compromise IOP homeostasis by impairing TM expression and function of TREK-1. Pharmacological activation of TREK-1 facilitates conventional outflow and could help lower IOP in eyes with steroid-induced ocular hypertension.
Authors
- Darryl R. Overby (ORCID: https://orcid.org/0000-0001-9894-7515)
- David Križaj (ORCID: https://orcid.org/0000-0003-4468-3029)
- Christopher L. Passaglia (ORCID: https://orcid.org/0000-0001-5902-9818)
- Oleg Yarishkin (ORCID: https://orcid.org/0000-0002-8215-7444)
- Sarah N. Redmon
- Christina M. Nicou (ORCID: https://orcid.org/0000-0002-4706-9369)
- Mónika Lakk (ORCID: https://orcid.org/0000-0001-5660-2623)
- Joseph M. Sherwood (ORCID: https://orcid.org/0000-0002-4402-9767)
- Christopher N. Rudzitis (ORCID: https://orcid.org/0000-0002-7271-5609)
- Jacques Bertrand
Institutions
- University of Utah (US)
- University of South Florida (US)
- Imperial College London (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1167/iovs.66.14.57
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Institutes of Health