Empirical Antifungal Therapy Improves Survival in Patients With Acute-on-Chronic Liver Failure With Suspected Invasive Fungal Infections: A Pragmatic Randomized Trial
Early empirical antifungal therapy within a structured stewardship framework improves survival in patients with ACLF and IFIs. Timely recognition, rapid diagnostics, and individualized antifungal strategies are essential to bridge these high-risk patients toward recovery or definitive therapies.
Authors
- Nusrat Shafiq (ORCID: https://orcid.org/0000-0001-7053-003X)
- Arunaloke Chakrabarti (ORCID: https://orcid.org/0000-0003-1555-3807)
- Madhumita Premkumar (ORCID: https://orcid.org/0000-0003-2961-4148)
- Arka De (ORCID: https://orcid.org/0000-0002-8567-1676)
- Nipun Verma (ORCID: https://orcid.org/0000-0003-4328-0914)
- Nimitha Mohan (ORCID: https://orcid.org/0000-0002-9431-1509)
- Arun Valsan (ORCID: https://orcid.org/0000-0002-8410-9665)
- Shankar Prinja (ORCID: https://orcid.org/0000-0001-7719-6986)
- Sunil Taneja (ORCID: https://orcid.org/0000-0003-3901-6969)
- Pratibha Garg (ORCID: https://orcid.org/0009-0002-3490-5855)
- Parminder Kaur (ORCID: https://orcid.org/0000-0003-2100-9867)
- Ajay Duseja (ORCID: https://orcid.org/0000-0003-3590-2664)
- Shreeja Sarabu (ORCID: https://orcid.org/0009-0002-8167-3954)
Institutions
- Amrita Institute of Medical Sciences and Research Centre (IN)
- Aster Medcity (IN)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.14309/ajg.0000000000003832
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00