On the Correlation Between Gastrointestinal Symptoms and Sites for Endoscopic Biopsies to Diagnose Graft-Versus-Host Disease

Symptom-guided endoscopic evaluation in GI-GVHD yields high diagnostic accuracy. Flexible sigmoidoscopy with targeted biopsies should be considered for patients with LGI symptoms because it may reduce procedural burden and health care costs without compromising diagnostic yield. These findings support symptom-directed, anatomically targeted approaches to improve patient care and resource utilization.