Higher blood flow rates in anticoagulation-free CRRT improve circuit survival and clinical outcome
A BFR of 250 ml/min significantly improved circuit survival in anticoagulation-free CRRT compared to 200 ml/min, likely mediated by TMP reduction. Moreover, patients receiving 250 ml/min BFR exhibited lower in-hospital mortality. Our results support adopting a higher BFR to optimize CRRT efficacy in anticoagulation-free settings. Larger-scale prospective trials are needed to validate the findings.
Authors
- Yuliang Zhao (ORCID: https://orcid.org/0000-0001-7660-452X)
- Yongxiu Huang (ORCID: https://orcid.org/0000-0002-1395-8299)
- Ling Zhang (ORCID: https://orcid.org/0000-0001-8371-5252)
- Fang Wang (ORCID: https://orcid.org/0000-0002-4504-0271)
- Liyao Yang
- Qian Bu (ORCID: https://orcid.org/0000-0003-1316-2423)
- Ping Fu
- Wei Wei (ORCID: https://orcid.org/0000-0002-4109-3878)
- Caihong Liu (ORCID: https://orcid.org/0000-0002-8582-912X)
- Zhiwen Chen (ORCID: https://orcid.org/0000-0001-5147-6269)
- Yingying Yang (ORCID: https://orcid.org/0000-0001-6779-080X)
- Xue Tang (ORCID: https://orcid.org/0000-0002-9280-4887)
- S T Fan
Institutions
- Changzhi Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/ckj/sfaf360
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- National Key Research and Development Program of China