A Novel Evaluation of 24-hour Energy Metabolism in Cushing's Syndrome: The Metabolic Cost of Hypercortisolism
Using a whole-room indirect calorimetry, we have demonstrated that chronic active hypercortisolism in patients with CS is associated with a reduction in 24hEE, likely driven by the progressive loss of lean soft tissue due to sustained increase in protein oxidation.
Authors
- Claudio Urbani (ORCID: https://orcid.org/0000-0002-2207-4727)
- Alberto Landi (ORCID: https://orcid.org/0000-0002-0105-5121)
- Alessio Basolo (ORCID: https://orcid.org/0000-0001-6888-7080)
- Isabella Lupi (ORCID: https://orcid.org/0000-0003-1010-3110)
- Jonathan Krakoff (ORCID: https://orcid.org/0000-0001-6074-5600)
- Roberta Jaccheri
- Paola Fierabracci
- Ferruccio Santini (ORCID: https://orcid.org/0000-0002-1706-0822)
- Maria Fleseriu (ORCID: https://orcid.org/0000-0001-9284-6289)
- Paolo Piaggi (ORCID: https://orcid.org/0000-0003-2774-9161)
- Chiara Bologna
- Véronique Angéli (ORCID: https://orcid.org/0009-0007-6730-6468)
- Edda Vignali
- Luca Manetti (ORCID: https://orcid.org/0000-0001-9911-5366)
- Luca Chiovato (ORCID: https://orcid.org/0000-0001-7457-7353)
- Guido Salvetti
Institutions
- University of Pisa (IT)
- Oregon Health & Science University (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Istituti Clinici Scientifici Maugeri (IT)
- Neurological Surgery (US)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1210/jendso/bvaf186
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dipartimenti di Eccellenza
- European Society for Clinical Nutrition and Metabolism