CARINH, an Interferon-Induced LncRNA in Cancer and Inflammation

<i>CARINH</i> is an intriguing long noncoding RNA whose unique regulatory functions intersect the seemingly distinct processes of innate immunity and cancer development. Notably, <i>CARINH</i> is conserved across species, offering powerful experimental models for uncovering its mechanistic roles and physiological functions across diverse biological contexts. Stimulated by interferons and viral infections, <i>CARINH</i> stands out as a key player in the body's antiviral defense mechanisms. Additionally, its dysregulation has been implicated in autoimmune disorders such as psoriasis, asthma, and inflammatory bowel disease, underscoring its broader role in maintaining immune homeostasis. Furthermore, alterations in <i>CARINH</i> expression have been connected to cancer progression, highlighting its dual role in immune response and tumor suppression. In this review, we delve into <i>CARINH</i>'s pivotal function in modulating interferon responses and influencing cancer development, with a focus on the molecular pathways that regulate its expression and contribute to its diverse roles. Understanding these pathways is crucial for evaluating <i>CARINH</i>'s significance as a biomarker and therapeutic target, potentially leading to groundbreaking advancements in medical research and treatment strategies.