Histological analysis of thrombus composition in acute ischemic stroke with large vessel occlusion: impact of r-tPA treatment
This study quantified the thrombus components of different etiologies and found that IVT could reduce the FIB content in thrombi of large artery occlusion cerebral infarction, especially in the LAA type. The platelet content in the LAA type was higher than that in the CE and the SUE types. The FIB level in the SUE type was higher than that in the CE type. FIB was not only present in the PLT area but also in the RBC area. IVT may improve thrombectomy success by disrupting thrombus structure, but it can increase fragment embolization and prolong procedure time.
Authors
- Changzhi Zhao
- Zhiliang Guo
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0002-6637-7025)
- Yang Zhang (ORCID: https://orcid.org/0009-0005-3724-9656)
- Ping Lei (ORCID: https://orcid.org/0000-0002-8410-7715)
- Sha Chen (ORCID: https://orcid.org/0000-0003-1387-9133)
- Qiao Li
- Guofang Chen
- Man-Hua Ding
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Xuzhou Cancer Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fnins.2025.1707934
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Soochow University
- Xuzhou Medical University
- Xuzhou Science and Technology Bureau